• BEACON: Efficient and Specific Base Editor with Low DNA Damage
    On June 3, 2020, a research article entitled “Cas12a Base Editors Induce Efficient and Specific Editing with Low DNA Damage Response” was published online in Cell Reports.  This work was done by a team led by Dr. Chen Jia from School of Life Science and Technology (SLST) at ShanghaiTech University, Dr. Yang Li from CAS-MPG Partner Institute for Computational Biology and Dr. L...
  • Scientists from ShanghaiTech and Tsinghua Universities Discover a Novel Neuroimmune Pathway
    On 29 April 2020, a research work carried out collaboratively by Professors Qi Hai and Zhong Yi from Tsinghua University and Professor Hu Ji from the School of Life Science and Technology (SLST) of ShanghaiTech University was published in Nature entitled “Brain control of humoral immune responses amenable to behavioural modulation”. The researchers identify a specific brain-spleen neur...
  • SLST Researchers Report a Novel Unwinding Model of a DNA Repair-Involved Helicase
    Recently, different research teams led by Professor Sun Bo from SLST and Professor Xi Xu-Guang from French National Centre for Scientific Research (CNRS) have collaboratively published a research article entitled “Human RPA activates BLM's bidirectional DNA unwinding from a nick” in the journal eLife, revealing a novel unwinding model of a DNA-repair-i...
  • CRUIS Captures RNA-Protein Interaction
    Groups of professors Liu Ji-Long,Zhuang Min, and Lu Pengfei from the School of Life Science and Technology (SLST) at ShanghaiTech University have jointly developed a new method CRUIS, or CRISPR-based RNA-United Interacting System, for capturing RNA-protein interactions on specific RNAs. It is a hybrid of two molecular machineries, CRISPR-based RNA-targeting Cas nuclease (dCas13a) and a proximity-...
  • SLST Lab Identifies a New Function of a Traditional Tight Junction Protein
    A team of scientists led by Professor Lu Pengfei from SLST has unexpectedly identified that the traditional tight junction protein Occludin does not act as a barrier in epithelial tissue as expected. Instead, Occludin plays a vital role in the regulation of extremely basic and important protein production and secretion. On February 13th, 2020, the work from Lu's lab was publishe...
  • Iterative Affinity MS Approach Accelerates GPCR Ligand Screening
    Analytical Chemistry
    iHuman Institute and SLST Professor Shui Wenqing’s group published a review in Current Opinion in Biotechnology in October 2019, “Systematic mapping of protein-metabolite interactions with mass spectrometry-based techniques”. This review presents a comprehensive overview of chemical proteomics techniques developed for probing protein-metabolite interactions in the cell. Shui Wenqing’...
  • Discovery of Common Activation Mechanism for Class A GPCRs
    A research group led by iHuman Institute and SLST Assistant Professor Zhao Suwen, working with Professor Wang Ming-Wei from Shanghai Institute of Materia Medica/The National Center for Drug Screening/Fudan University and Professor Babu Madan from MRC Laboratory of Molecular Biology, recently discovered a common activation pathway in class A GPCRs. Their study, “Common activation mechanism of clas...
  • New Findings on Adrenergic Receptors Shed Light on Partial Agonism and Biased Signalling
    Cell Reports
    Recently, a collaborative study led by Assistant Professor Zhao Suwen and Assistant Professor Zhong Guisheng at iHuman Institute and School of Life Science and Technology, and Research Associate Professor Wu Dong at iHuman Institute reported two crystal structures of human α2A adrenergic receptor (α2AAR) in complex with a partial agonist and an antagonist, and discovered key non-conserved r...
  • SLST Completes First 5-Yr Review
    A committee of twelve internationally renowned scientists carried out the first quinquennial review (QQR) on the development and progress of the School of Life Science and Technology (SLST) from 15th-18th November 2019.The committee was warmly welcomed by University Council Chairman Li Ruxin. Vice President and Provost Yin Jie introduced the brief history of ShanghaiTech University since its estab...
  • Life Science Trio Holds ShanghaiTech BioForum
    On November 10-14th, the 2019 ShanghaiTech BioForum was successfully held at ShanghaiTech University. For the first time, the BioForum was jointly organized by the three life science institutions of ShanghaiTech University - School of Life Science and Technology (SLST), Shanghai Institute for Advanced Immunochemical Studies (SIAIS) and iHuman Institute (iHuman), which compose the “ShanghaiTech Li...
  • Tumor Immunogenicity Score Impacts Immunotherapy Response
    A tumor immunogenicity score (TIGS), a novel cancer immunotherapy biomarker, was proposed by a research team from the School of Life Science and Technology (SLST) led by Assistant Professor Liu Xuesong. The study describing TIGS was published online in the journal eLife on November 26th. This tumor immunogenicity-based biomarker could guide the treatment to transform some immunotherapy n...
  • New BEable-GPS Database A Valuable Resource for Researchers
    Genome Biology
    A study published in Genome Biology systematically compares a panel of BEs for the first time and BEable-GPS is the first database to profile the accessibility of BEs to target pathogenic SNVs. BEable-GPS and its embedded toolsets will provide researchers a great resource for their experimental designs to model or correct disease-related mutations.This study results from a collaboration betwe...
  • New High-Res Map Explains spCas9- DNA Interplay
    Science Advances
    Research teams led by Professor Sun Bo from SLST and Professor Shen Bin from Nanjing Medical University have completed a high-resolution quantitative map of Cas9/sgRNA/DNA interactions (Figure 1). On November 13, 2019, their study was published as a research article entitled, “The post-PAM interaction of RNA-guided spCas9 with DNA dictates its target binding and dissociation," in the journal...
  • Mechanism Advances Fight Against TB-Drug Resistance
    Nature Communications
    On August 29th, 2019, a study led by a collaboration between ShanghaiTech Adjunct Professor Rao Zihe and SLST Adjunct Professor and CAS Institute of Biophysics Hu Junjie’s group was published online in Nature Communications. In the research article, “Mycobacterial dynamin-like protein IniA mediates membrane fission,” they reported the crystal structure of IniA, an isoniazid inducible protein, w...